David A. Edwards
Gordon McKay Professor of the Practice of Biomedical Engineering
School of Engineering and Applied Sciences
Harvard University
322 Pierce Hall
Cambridge, MA 02138
Phone: (617) 495-1328
Fax: (617) 495-9837
dedwards@deas.harvard.edu

BIO | HONORS AND AWARDS | PUBLICATIONS | PATENTS

TEXTBOOKS

1. Brenner, H. and Edwards, D.A. 1993 Macrotransport Processes. Boston, MA: Butterworth-Heinemann, 744 pp.

2. Edwards. D.A., Brenner, H. and Wasan, D.T. 1991 Interfacial Transport Processes and Rheology. Boston, MA: Butterworth-Heinemann, 558 pp.

ARTICLES

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1. Edwards, D.A. 1987 Surface Rheology. Ph.D. Thesis. Chicago: Illinois Institute of Technology.

2. Edwards, D.A. & Wasan, D.T. 1988 Surface Rheology I. The planar fluid surface. J. Rheology 32, 429-445.

3. Edwards, D.A. & Wasan, D.T. 1988. Surface Rheology II. The curved fluid surface. J. Rheology 32, 446-472.

4. Edwards, D.A. & Wasan, D.T. 1988. Surface Rheology III. Stress on a spherical fluid surface. J. Rheology 32, 473-484.

5. Edwards, D.A. & Wasan, D.T. 1988. Dilatational properties of adsorbed surfactant interfaces and their applications. In Surfactants in Chemical/Process Engineering, vol. 28 (eds. D.T. Wasan, M.O. Ginn and D.O. Shah), pp. 1-28.

6. Wasan, D.T., Nikolov, A.D., Huang, D.W. & Edwards, D.A. 1988 Foam stability: Effects of oil and film stratification. In Surfactants-Based Mobility Control, vol. 373 (ed. D.H. Smith), pp. 136-162.

7. Edwards, D.A. Brenner, H. & Wasan, D.T. 1989 On a relation between foam and surface dilatational viscosities. J. Colloid Interface Sci. 130, 266-270.

8. Nikolov, A.D., Wasan. D.T., Huang, D.W. & Edwards, D.A. 1989 The effect of oil on foam stability: mechanisms and implications for oil displacement by foam in porous media. SPE J. 32, 446-472.

9. Kao, R., Nikolov, A.D., Wasan, D.T. & Edwards, D.A. 1989 Crude oil droplet removal from a solid silica surface in the presence of anionic micellar solutions. J. Colloid Interface Sci. 32, 446-472.

10. Kao, R., Wasan, D.T., Nikolov, A.D. & Edwards, D.A. 1989 Mechanisms of oil removal from a solid surface in the presence of anionic micellar solutions. Colloids and Surfaces 34, 389-398.

11. Edwards, D.A., Shapiro, M., Bar-Yoseph, P. & Shapira, M. 1990 The influence of Reynolds number upon the apparent permeability of spatially periodic, two-dimensional arrays of cylinders. Phys. Fluids A 2, 45-55.

12. Edwards, D.A. & Wasan, D.T. 1990 Foam dilatational rheology I. Dilatational viscosity. J. Colloid Interface Sci. 139, 479-487.

13. Edwards, D.A. & Wasan, D.T. 1990 A micromechanical model of linear surface rheological behavior. Chem. Engng Sci. 46, 1247-1257.

14. Edwards, D.A., Shapiro, M., Brenner, H. & Shapira, M. 1991 Dispersion of inert solutes in spatially periodic, two-dimensional, model porous media. Transport in Porous Media 6, 337-358.

15. Edwards, D.A. & Wasan, D.T. 19996 Interfacial and thin film hydrodynamics in the rheology of foams. In Foams. Surfactant Science Series (ed. Prudhomme and S.A. Khan), pp 189-215 New York: Marcel Dekker Inc.

16. Kao, R., Edwards, D.A. Wasan. D.T. & Chen, E. 1992 Measurement of the surface dilatational viscosity at hight rates of surface expansion using the maximum bubble pressure method. I. Gas-Liquid Surface. J. Colloid Interface Sci. 148, 247-256.

17. Kao, R., Edwards, D.A. Wasan. D.T. 1992 Measurement of the interfacial dilatational viscosity at high rates of interface expansion using the maximum droplet pressure method. II. Liquid-Liquid Interface. J. Colloid Interface Sci. 148, 257-260.

18. Wasan, D.T., Nikolov, A.D., Lobo, L.A., Koczo, K. & Edwards, D.A. 1992 Foams, Thin Films and Surface Rheological Properties. Progress in Surface Science. 139, 119-154.

19. Edwards, D.A., Shapiro, M. & Brenner, H. 1993 Convective-dispersion within reactive, spatially periodic, two dimensional, model porous media. Phys. Fluids. A. 5, 837-848.

20. Mavrovouniotis, G., Brenner, H., Edwards, D.A. & Ting, L. 1993 A micromechanical investigation of interfacial transport processes. II. Interfacial conservation equations. Proc. Roy. Soc. (London) A35, 209-228.

21. Oron, A. & Edwards, D.A. 1993 Stability of a Falling Liquid Film in the Presence of Interfacial Viscous Stress. Phys. Fluids. A.5, 506-508.

22. Edwards, D.A., Gidaspow, D. & Dawson, M. 1993 Darsh Wasan: 1991 outstanding educator. Chemical Engineering Education, 26, 2-7.

23. Batycky, R.P., Edwards, D.A. & Brenner, H. 1993 Thermal dispersion in an insulated circular cylinder—I. Theory. Int. J. Heat and Mass Transfer 36, 4317-4325.

24. Batycky, R.P. Edwards, D.A. & Brenner, H. 1993 Thermal dispersion in an insulated circular cylinder—II. Applications. Int. J. Heat and Mass Transfer 36, 4327-4333.

25. Edwards, D.A., Kao, R. & Wasan, D.T. 1993 Response to Kostas Avramidis’ “Comments on measurement of interfacial dilatational viscosity at high rates of interfacial expansion using the maximum bubble pressure method.” J. Colloid Interface Sci. 155, 518-519.

26. Batycky, R.P., Edwards, D.A. & Brenner, H. 1994 Internal energy transport in adiabatic systems. Thermal Taylor dispersion phenomena. Int. J. Nonlinear Mech. 29, 639-664.

27. Edwards, D.A. 1994 The macrotransport theory of nondepositing particles in the lung by convective dispersion. J. Aerosol Sci. 25, 533-565.

28. Edwards, D.A. and Langer, R. 1994 A linear theory of transdermal transport phenomena. J. Pharm. Sci. 83, 1315-1334.

29. Batycky, R.P., Edwards, D.A. & Brenner, H. 1994 Internal energy transport in nonadiabatic systems. Thermal Taylor dispersion phenomena. Chem. Engng. Commun. 130, 53-104.

30. Edwards, D.A. 1995 The macrotransport theory of lung dispersion: Aerosol deposition phenomena. J. Aerosol Sci. 26, 293-317.

31. Edwards, D.A. 1995 Charge transport through a spatially periodic porous medium: electrokinetic and convective dispersion phenomena. Phil. Trans. Roy. Soc. Lond. A353, 205-243.

32. Batycky, R.P. & Edwards, D.A. 1996 Microscopic and macroscopic descriptions of gas and aerosol transport in the lungs. Chem. Engng. Commun. 148-150, 23-39.

33. Edwards, D.A. & Oron, A. 1995 Instability of a nonwetting film with interfacial viscosities. J. Fluid Mech. 298, 287-309.

34. Edwards, D.A. & Davis, A.M.J. 1995 Diffusion and convective dispersion through arrays of spheres with surface absorption, diffusion and unequal solute partitioning. Chem. Eng. Sci. 50, 1441-1454.

35. Edwards, D.A., Prausnitz, M. & Langer, R. 1994 Analysis of enhanced transdermal transport by skin electroporation. J. Contr. Rel. 34, 211-221.

36. Mitragotri, S., Edwards, D.A., Blankshtein, D. and Langer, R. 1995 A mechanistic study of ultrasonically enhanced transdermal drug delivery. J. Pharm. Sci. 84, 697-706.

37. Li, W.I., Perzl, M., Heyder, J., Langer, R., Brain, J., Niven, R. and Edwards, D.A. 1996 Aerodynamics and aerosol particle deaggregation phenomena in model oropharyngeal cavities. J. Aerosol Sci. 27, 1269-1286.

38. Chen, H., and Edwards, D.A., 1996 A generalized theory of phagocytosis. J. Colloid Interface Sci. 190, 118-133.

39. Ferron, G. and Edwards, D.A. and Niven, R.W. 1996 Numerical simulation of air and particle transport in the conducting airways. J. Aerosol Med. 9, 303-316.

40. French, D.L., Edwards, D.A. and Niven, R.W. 1996 Influence of formulation on the emission, deaggregation and deposition of dry powders for inhalation. J. Aerosol Sci. 27, 269-783.

41. Edwards, D.A., Gooch, K.J., Zhang, I., McKinley, G.H. and Langer, R. 1996 The nucleation of receptor-mediated endocytosis. Proc. Natl. Acad. Sci. 93, 1786-1791.

42. Edwards, D.A., Schneck, F., Zhang, I., Davis, A.M.D., Chen, H., Langer, R. 1996 Spontaneous vesicle formation at lipid bilayer membranes. Biophys. J. 71, 1208-1214.

43. Zhang, I., Shung, K. and Edwards, D.A. 1997 Hydrogels with enhanced mass transfer for transdermal drug delivery. J. Pharm. Sci. 85, 1312-1316.

44. Batycky, R., Hammerstedt, R. and Edwards, D.A. 1997 Osmotically driven intracellular transport phenomena. Phil. Trans. Roy. Soc. Lond. A355, 2459-2488.

45. Batycky, R., Hanes, J., Langer, L. and Edwards, D.A. 1997 A theoretical model of erosion and macromolecular release from biodegrading microspheres. J. Pharm. Sci. 86, 1464-1477.

46. Hanes, J., Batycky, R., Edwards, D.A. and Langer, R. Poly-DL-latic-co-glycolic acid microsphere degradation and pulsatile release of the globular protein GP120, J. Pharm. Sci (submitted).

47. Li, W.-I and Edwards, D.A. 1997 Aerosol transport and deaggregation phenomena in the mouth and throat. Advanced Drug Delivery Reviews (ed. R. Niven), 26, 41-48.

48. Stoll, B.R., Batycky, R.P., Leipold, H.R., Milstein, S. and Edwards, D.A. 1999 A theory of molecular absorption from the small intestine. Chem. Eng. Sci. 55, 473-489.

49. Edwards, D.A., Hanes, J., Caponetti, G., Hrkach, J., Ben-Jebria, A., Eskew, M.L., Mintzes, J., Lotan, N., and Langer, R. 1997 Large porous biodegradeable particles for pulmonary drug delivery. Science. 276, 1868-1871.

50. Edwards, D.A., Ben-Jebria, A. and Langer, R. 1998 Recent advances in pulmonary drug delivery using large porous inhaled particles. (Invited Review) J. Appl. Physiol. 84, 379-385.

51. Li, W. –I., Perzl, M.P., Ferron, G.A., Batycky, R., Heyder, J. and Edwards, D.A. 1998 The macrotransport of particles in the human oral-pharyngeal region. J. Aerosol Sci. 29, 995-1010.

52. Edwards, D.A., Chen, D., Wang, J. and Ben-Jebria, A. 1998 Controlled release inhalation aerosols. Resp. Drug Delivery VI., Hilton Head, SC, 187-192.

53. Wang, J., Ben-Jebria, A. and Edwards, D.A. 1999 Inhalation of estradiol for sustained systemic delivery. J. Aerosol Medicine, 12, 27-36.

54. Ben-Jebria, A., Chen, D., Vanbever, R., Langer, R. and Edwards, D.A. 1999 Inhalation of large porous albuterol particles for sustained bronchodilation. Pharm. Res. 16, 555-561.

55. Batycky, R., Nice, J., Chen, D., Sung, J., Lipp, M., Mintzes, J., Dunbar, C., Niven, R. and Edwards, D.A. 1999 Production and characterization of large porous particles for pulmonary drug delivery. Materials Research Society, Boston, MA, 16, 555-561.

56. Stoll, B.R., Leipold, H.R., Milstein, S. and Edwards, D.A. 2000 A mechanistic analysis of carrier-mediated oral delivery of protein therapeutics. J. Controlled Release 64, 217-228.

57. Edwards, D.A., Caponetti, G., Johnston, L., Hrkach, J., Batycky, R., Niven, R., Strowitzki, T., Thaler, C.J., Kohlhaufl, M., Brand, P., Scheuch, G., Heyder, J., Haussinger, K. and Schulz, H. 1999 Novel therapies with large porous particles: human trial results. Ninth International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, UT.

58. Edwards, D.A., Hrkach, J., Schmitke, J., Berkovitz, D., Yancey, D., Johnston, L. and Niven, R. 1999 Protein delivery by inhalation of large porous particles. ACS Symposium Drug Delivery in the 21st Century, Anaheim, CA.

59. Edwards, D.A. 1999 Controlled release in the respiratory system. In Encyclopedia of Controlled Drug Delivery (E. Mathiowitz, ed), Wiley & Sons; NY, NY, V2, 936-941.

60. Vanbever, R., Mintzes, J.D., Wang, J., Nice, J., Chen, D., Batycky, R., Langer, R. and Edwards, D.A. 1999 Formulation and physical characterization of large porous particles for inhalation. Pharm. Res. 16, 1735-1742.

61. Vanbever, R., Ben-Jebria, A., Mintzes, J.D., Langer, R., and Edwards, D.A. 1999 Sustained release of insulin from insoluble inhaled particles. Drug Dev. Research 48, 178-185.

62. Choi, W-S., Murthy, K.G.G., Edwards, D.A., Langer, R., and Klibanov, A.M., 2001 Inhalation delivery of proteins from ethanol solutions. Proceedings of the National Academy of Engineering, 98, 11103-11107.

63. Edwards, D. and Dunbar, C. 2002 Therapeutic aerosol bioengineering. Annual Reviews of Bioengineering, 4, 93-107.

64. Edwards, D.A. 2002 The delivery of biological agents by aerosols. Invited Perspective Review. AICHE Journal, 48, 2-6.

65. Tsapis, N., Bennett, D., Jackson, B., Weitz, D.A. and Edwards, D.A. Trojan particles: Large porous carriers of nanoparticles for drug delivery. Proceedings of the National Academy of Engineering, 99, 12001-12005.

66. Valenti, A., Stone, H., Langer, R., and Edwards, D.A. 2003 Recent advances in inhaled insulin delivery. BioDrugs., 17, 9-17.

67. Edwards, D.A., Valenti, A., Mann, J., Tsapis, N. 2003 New advances in the systemic administration of proteins by inhalation. To appear in Pharmaceutical Advances.

Tsapis, N., Bennett, D., O’Driscoll, K.O., Shea, K., Lipp, M.M., Fu, K., Clarke, R.W., Deaver, D., Yamins, D., Wright, J., Peloquin, C.A., Weitz, D.A. and Edwards, D.A. 2003 Direct delivery of para-aminosalicylic acid by aerosol particles. Tuberculosis. , 83, 379-385

69. Lombry, C., Edwards, D.A., Préat, V., and Vanbever, R. 2003 Alveolar macrophages are a primary barrier to pulmonary absorption of macromolecules. To appear: Am. J. Physiol. Cell Med.

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